Chitosan

Chitosan X-tra

A Unique Positive Ionic Fiber Supplement

Executive Summary:

Unique Benefits of Chitosan Plus:

Are We Losing the ‘Battle of the Bulge?’

More than 100 million overweight Americans spend about 33 billion dollars each year to try to lose weight. Americans are more closely following government and medical industry recommendations for diet today than they were a decade ago, yet in that time span, the average American has gained an average of 8 more pounds! It’s time for a new approach that focuses on rebuilding cellular health rather than counting calories. Enhanced nutrition is a key factor in the cell’s ability to burn fat and the body’s ability to attain and maintain optimum weight. Vitamin B6 (pyridoxine) is essential for converting stored fat into energy. Vitamin B5 (pantothenic acid) and protein are also needed to burn fat at an optimal rate. Amino acids are essential in the cell’s energy systems but require B vitamins like Choline and Vitamin B6 as well as other nutrients to be utilized. Vitamin E is necessary for fat utilization, doubling fat utilization. The B complex vitamins Choline and Inositol are needed to make lecithin which assists cellular fat utilization. Production of hormones and enzymes required for fat metabolism are similarly dependent on a wide range of nutrients, all of which are found in StarGold.

More Reasons to Fight Fat

Excess dietary fat is associated with more than just obesity. Excess dietary fat also reduces longevity. It is linked to killer cardiovascular problems including high blood pressure, stroke, coronary artery disease and heart disease. Related problems also include gallbladder disease, joint inflammation like gout and arthritis, liver and kidney problems, diabetes, respiratory difficulties, malnutrition, complications of pregnancy and psychological disorders. Even cancer is linked to excessive fat intake, including cancer of the breast, uterus, cervix, ovaries, prostate, colon and rectum. Colorectal cancer is the number one cancer in the U.S. Digestive tract disorders are responsible for more hospitalization than any other problem, with a total cost of more than $50 Billion every year. Most of these problems could be prevented by reducing dietary fat and increasing dietary fiber.

According to the Merck Manual, diverticulosis in the colon increased from 1O% of the population in 1950 to 50% 1987. The 1994 edition now reveals that 100% are expected to develop diverticuli. These pockets are filled with material so toxic that a quarter teaspoon would be lethal if absorbed into the blood. The average American stores 5 to 10 pounds of this excess fecal matter, and 10 to 20 pounds is not at all unusual. The constant, slow absorption of these toxins into the bloodstream contributes to cardiovascular disease and stresses every cell in the body. Diverticuli can be prevented with an adequate dietary fiber intake.

The Importance of Fiber

Dietary fiber is found in fruits, vegetables, whole grains, beans and seeds and not in meat, dairy products or refined foods. One benefit of fiber is that it binds to toxic bile acids and excess fats, reducing their absorption. Fiber provides bulk, producing a feeling of fullness which helps to reduce overeating. Fiber helps reduce bowel transit time, decreasing production and absorption of fecal toxins, while feeding the friendly flora. Fiber improves regularity, assists in elimination, aids digestion and helps clean the bowels. Fiber is also important in lowering cholesterol, reducing the risk of heart disease, lowering high blood pressure and improving blood sugar. Chitosan Plus (pronounced ‘Key-toe-sahn’) provides all of these fiber benefits and more. For example, studies on diabetes show that Chitosan controls both blood and urine sugar much better than plant fiber.

Chitosan is an aminopolysaccharide, derived from chitin which makes up the exoskeleton (shell) of crustaceans such as shrimp, lobster and crab. It has been the subject of over 1500 studies. We have 17 years of clinical research on chitosan as a natural weight loss, fiber and colon cleansing supplement. It has also been used for 30 years in water purification, due to its remarkable ability to absorb oil, grease, and other toxic substances. It is also used in food and beverage plants such as breweries and vegetable canneries. In oriental medicine, chitin has an even longer history of medicinal use.

Safe & Effective Weight Loss

Chitosan can produce dramatic weight loss as proven in a clinical study in Helsinki. Participants lost an average of 8% body weight in fat in just one month, an average of more than 15 pounds per person! Researchers say the participants "informed us that this chitosan was the best and most hygienic way to take a weight reducing substance." The absence of side effects was touted by the researchers and they were surprised at the blood pressure lowering effects of chitosan as well. This is good news for the 68% of Americans who are now overweight, and even more so the 33% of adults classified as obese. According to the New England Journal of Medicine, even a small amount of extra body weight increases our risk of disease and may affect longevity. The National Institute of Health states that, "Obesity is the leading cause of heart disease, hypertension, stroke, diabetes, and even cancer."

Chitosan Chemistry

Chitin is similar to cellulose except that acetylamino groups are present in place of hydroxy groups. Removing the acetyl groups, a process known as deacetylation, results in chitosan, an aminopolysaccharide molecule with a strong positive electrical charge, which strongly attracts and bonds to negatively charged molecules.

Once in the digestive system, chitosan dissolves and forms a positively charged ionic gel. Negatively charged molecules of fats, lipids, bile and acid-forming ions like chloride attach strongly to the chitosan sites where the acetyl groups were removed. This electrostatic bonding causes large polymer compounds to be formed that bypass the digestive process. The chitosan then acts as a coagulating agent for other high calorie molecules such as complex sugar chains and high caloric carbohydrate micelles. These are substances that often get converted into fat that then builds up in our cells. As the chitosan polymer grows, it becomes too large to be absorbed through the lining of the digestive tract. The polymer is then excreted as waste from the digestive system, carrying away the attached fat and other fat and acid producing substances.

It dissolves within the stomach itself and converts into a gel. Chitosan binds dietary cholesterol. The International Journal of Obesity has stated that adding dietary fiber to a low fat diet can help reduce hunger and increase the number of bowel movements; two actions which greatly enhance weight loss. Fiber has also been linked to slower rises in blood glucose which also profoundly affect how we store excess calories and when we feel hungry. Water purification plants throughout the nation use Chitosan for this purpose. What this indicated to scientists was that Chitosan can selectively absorb fats even in a water medium.

Bile acids are neutralized by the chitosan polymer. Bile acids are released from the liver and gall bladder when fats, lipids and other high calorie foods enter the small intestine. Bile breaks down the high calorie substances into small absorbable fat droplets called micelles. Micelles are either enzymatically digested or directly absorbed into the body. Chitosan attracts and binds up to half to 2/3 of these fat-producing micelles so they can be eliminated rather than absorbed. Bile acids also produce bile salts in the colon, considered the most toxic substances in the body, excess amounts of which may contribute to both colon and prostate cancer.

Chitosan is lipophilic, meaning that it is attracted to fat. Most fibers are hydrophilic, which means they repel fat and attract water. For example, straight psyllium fiber will absorb water, producing bulk while leaving fats behind that can contribute to constipation. Laboratory research comparing 23 different fibers proved that chitosan worked 55% better than the next best fiber for eliminating fat from the intestinal tract.

The degree of negatively charged fat, lipid, cholesterol, complex sugar chains, or high calorie carbohydrates bound by chitosan is in direct proportion to the degree of deacetylation. Pharmaceutical grade chitosan is deacetylated between 90 to 95% and can absorb 10 to 12 times it weight. Food grade chitosan is deacetylated between 75 to 80% but only binds 4 to 6 times it's weight. Thus, when purchasing chitosan, the percentage of deacetylation is important in getting maximum benefits.

Cholesterol Reduction

A clinical study found chitosan reduced total cholesterol by 32% in just 5 weeks. At the same time, beneficial HDL cholesterol, which helps to prevent atherosclerotic plaque, increased by 7.5%. Triglyceride levels are reduced by 18% over the same period. Other studies show decreased concentrations of liver cholesterol. A Japanese study on rats found that chitosan decreased liver cholesterol by 60% in just 4 weeks. Pharmaceutical grade chitosan was shown to be as effective as the best prescription drugs available for lowering cholesterol. Unlike the drugs, however, there are no side effects from chitosan and the cost is much less, as well. Chitosan can also have a major impact on reducing high blood pressure, heart disease, and other cardiovascular problems.

In a study at Tottori University, it was found that rabbits fed a high cholesterol diet showed increased cholesterol levels and developed hypertrophic, discolored livers. With the addition of Chitosan to the same diet, cholesterol levels were lower by 430 mg and the livers were normal and healthy. Encouraged by these hepatoprotective results, Japanese doctors then found good clinical effects in Hepatitis B and C, fatty liver, liver cirrhosis, liver cancer and alcohol hepatitis. Others report that taking Chitosan before exposure to alcohol helps to prevent symptoms of drunkenness as well as hangovers.

Professor Sugano summarizes, “Chitosan has a strong plus charge, which absorbs bad cholesterol and removes it from our body. On the other hand, chitosan increases good HDL cholesterol. Western medicine has cholesterol-lowering agents, but cannot do the different actions simultaneously like chitosan does. Chitosan’s action should be considered to be controlling or normalizing action for cholesterol and neutral fats rather than merely an action of lowering cholesterol.” The beneficial HDL cholesterol increased by Chitosan is considered to be essential for cellular regeneration, while LDL cholesterol contributes to atherosclerosis, blocking cellular oxygenation and nutrition.

Reducing High Blood Pressure

Sixty percent of people with essential hypertension can reduce their blood pressure by restricting sodium chloride, or salt, intake. In America, these people are called sodium sensitive, but Japanese research with Chitosan has proved that it is actually the chloride ions which are to blame. Professor Hiromichi Okuda at Ehime University School of Medicine and Professor Hideo Katoh of Hiroshima Women’s University showed that both in animals and humans with salt-sensitive hypertension, the addition of negatively charged plant fibers to the diet had no effect on the increased blood pressure, but positively charge Chitosan fiber prevented dietary salt from increasing blood pressure. Because sodium is a cation (positive charge) it is attracted to plant fibers and excreted in the stool, while these typical dietary fibers permit chloride ions to be absorbed. They found that chloride then activates Angiotensin-converting enzyme, which synthesizes Angiotensin I into Angiotensin II, the major trigger of essential hypertension. Chitosan, the only fiber with a positive electrical charge, binds the anionic (negatively charged) chloride ions preventing their absorption. In one study, average blood pressures, with the same salt intake, were 200 with regular fiber, but dropped to 120 with Chitosan. Experiments to determine the minimum dosage to block chlorines hypertensive effects found that just 500 mg completely prevented any increase in the blood levels of chlorine. Professor Okuda states, “We could say that 60% of essential hypertensive patients should take 0.5 gram of chitosan right after their meals and would not need the tasteless food which is called ‘low salt diet.’ Chitosan controls (an increase of chlorine and) an increase of blood pressure.”

Chloride also stresses triggers abnormal secretion of insulin from the pancreas. As Professor Hideo Katoh explains, “This insulin increase leads to blood pressure elevation. Insulin also works to make body accumulate fats and promotes obesity. And obesity, in turn, triggers possibly diabetes. . .” By binding to both chloride and sugars, Chitosan thus also helps to regulate diabetes as well as the related condition of obesity. At the same time it is helping to improve circulation, regulate blood pressure, and even reduce atherosclerosis. The overall effect of activating and stimulating cell metabolism results in prevention and even reversal of age-related symptoms. Many users even report gradual darkening of grey hair and lessening of skin wrinkles.

Chitosan is a traditional Japanese remedy with hundreds of years of clinical use:

No wonder over 2 million Japanese take Chitosan every day!

Still More Uses Discovered:

• Acne: Chitosan has been used effectively because it inhibits the specific bacteria which cause the inflammation associated with acne.
• Agriculture: Chitosan can be coated on seeds, resulting in increased crop yields, since chitosan induces a protective response in the germinating plant. When Chitosan is used as a fertilizer, no chemicals are needed because plants are naturally stronger. Plants normally absorb small amounts of chitin from the insects they come in contact with. It seems that the use of insecticides has actually reduced the level of chitin in plants, by killing the insects that produce it. This has resulted in weaker plants, and also less chitin in the food chain for human consumption as well.
• Antacid: A patent has been issued for using Chitosan as a safe and highly effective antacid.
• Antibiotic Resistance: Chitosan is being used to prevent and control nosocomial (hospital) infections from methicillin-resistant Staphylococcus aureus (MRSA).
• Arthritis: Enzymes produced by friendly flora produce Glucosamine from Chitosan. Glucosamine has been found to decrease the pain and disability of arthritis, while helping to repair damages joint tissues. Chitosan Plus can be taken together with Friendly Flora to enhance this effect.
• Burn Treatment: Chitosan can form tough, water-absorbent, biocompatible films directly on a burn by application of an aqueous solution of chitosan acetate (chitosan dissolved in dilute vinegar and then further diluted before application). The solution, although acidic, provides a cool and pleasant soothing effect when applied to the open wounds of burn patients. Another advantage of this type of chitosan treatment is that it allows excellent oxygen permeability. This is important to prevent oxygen-deprivation of injured tissues. Additionally, chitosan films have the ability to absorb water and are naturally degraded by body enzymes. This fact means that the chitosan needs not be removed. In most injuries, and especially burns, removing the wound dressing can cause further damage to already injured tissues.
• Calcium: Clinical tests show that Chitosan increases the bio-availability of calcium.
• Candida: Fungal overgrowths, especially Candida albicans affects millions of people. In vivo clinical studies show that chitosan effectively kills Candida.
• Cell Biology: Chitosan aggressively binds to a variety of mammalian and microbial cells, leading to possible applications as a hemostatic and bacteriostatic agent. Chitosan can be referred to as a polycation. Since the early 1950s, polycations have been known to bind to red blood cells. Many studies since have shown that polycations are effective cellular agglutinating agents. In the early 1960s, chitosan was investigated for its agglutinating and binding abilities. It was found that chitosan, even at very low concentrations, had the ability to agglutinate red blood cells. This led to chitosan's consideration as a hemostatic agent. The agglutination of red blood cells by polycations is dependent both on polymer structure and molecular weight. Out of six common polycations, only chitosan was able to effectively initiate gel formation of heparinized blood. Chitosan with a molecular weight of 35,000 was able to produce a loose coagulum in heparinized blood, while chitosan with molecular weights of 600,000 or above produced firm coagulum. The normal repulsive force between red blood cells is due to the high net negative charge on the cell membranes. This high negative surface charge is predominantly due to the presence of neuraminic acid, which binds to Chitosan’s positive charges.
• Detoxification: Chitosan chelates heavy metals, radioactive materials and other toxins, decreasing absorption of toxins in food and water, while preventing re-uptake of wastes excreted by the liver, a common problem sometimes referred to as ‘toxic ping-pong.’ In fact, water purification plants throughout the nation use Chitosan to detoxify oils, heavy metals and other potentially toxic substances. Doctors in Japan find that Chitosan reduces side effects of synthetic medications, too. And after the Chernobyl disaster, Doctors from the Ukraine travelled to Japan to learn how Chitosan could reduce the effects of radiation on the immune system. Later, Dr. Zemskoff of the National Kiev Clinical Research Hospital concluded that Chitosan had decreased pain and fatigue while improving appetite, motivation to live and other quality of life (QOL) indicators for radiation patients there. They noted increased physiological activation and it was concluded that Chitosan is effective against radiation sickness. Measurements of Chitosan’s ability to adsorb and excrete radioactive elements showed that in just 2 weeks, over 50% of the K70 and Ru106 was detoxified and over 65% of the Cs137 was eliminated as well. It appears to be wise to keep a supply of Chitosan on hand in case of any nuclear disaster.
• Immunity: Recent studies reveal that Chitosan stimulates the immune system. Chitosan also reduces immune stress as shown by a reduction in the number of macrophages in the bloodstream. Natural Killer cells are increased 4 to 5 fold.
• Plaque: Studies using chitosan in chewing gum show that chitosan increases the saliva pH and actually binds to the bacteria that cause plaque and tooth decay. Openning Chitosan capsules in the mouth could provide similar benefits.
• Skin Problems: Dr. Akemi Kataoka reports on her extensive clinical application of Chitosan, “It is effective against various bacteria and fungi. Our clinic cures well athlete’s foot, psoriasis and skin diseases that Western medicine has a difficulty treating, by giving chitosan orally or applying it topically to the skin.” Chitosan combines its antimicrobial powers with immune activation and improved wound healing abilities. In additional to oral use, it can be dissolved in dilute vinegar (acetic acid) and then either added to bath water (about 2/3 of an ounce) or diluted for direct topical application to problem skin areas. Taking the solution orally can also be helpful for problems in the mouth and esophagus.
• Tumors: Chitosan impairs tumor growth in vivo, yet studies show no toxic or allergic side effects on animals even when consuming up to 1O% Chitosan in their daily diet. Chitosan increases NK cells that selectively kill cancer cells by a factor of 4 to 5 times. A study of 800 people at Saitama Cancer Center found the the higher the NK cell activity is, the lower is the liklihood of cancer. Chitosan increases another type of lymphocyte, the LAK cell, as well, enhancing the immune system’s cancer killing activity another 3-fold. In addition, Chitosan relieves cancer pain by counteracting Toxohormone ‘L’ which is excreted by cancer cells. Dr. Ichiro Azuma, president of Immunology Institute at Hokkaido University reports that Chitosan prevents cancer metastasis as well. Chitosan prevents cancer cells from getting into the blood vessels, and furthermore prevents any present in the blood from getting out into the tissues to seed a new tumor. In one study, isolated components of Chitosan even blocked cancer cell reproduction, one by 85% and another by 93%. No wonder the Japanese are calling Chitosan a “Nobel Prize” substance.
• Wound Healing: Chitosan helps blood to coagulate, an important step in healing injured tissues. A Chitosan solution applied topically to wounds inhibits scar-forming fibroblasts, while accelerating wound healing by over 30%. Standard sutures coated with chitosan show wound-healing activities only slightly lower than all-chitin fibers. Surgical gauze coated with chitosan demonstrates substantially greater activity than an uncoated control group. Surgical grafts connecting major arteries also show reduced leakage when using Chitosan.

Quality and Effectiveness

Food grade chitosan has been shown in both "in vitro" and "in vivo" studies to bind 4 to 6 times its weight in fat. When combined with ascorbic acid, its ability to bind lipids increases to 6 to 8 times. Clinical studies show that when ascorbic acid is added to pharmaceutical grade chitosan its effectiveness is almost doubled. Chitosan can bind as much as half to two thirds of the high calorie foods we eat.

Recommended Use: Take 2-4 capsules, or more if body weight is over 150 pounds, with an eight ounce glass of water up to 30 minutes before heavy meals. Take more with high fat content meals. Japanese doctors recomend a total of 4 capsules per day for health maintenance, 6 to 8 for chronic discomfort or fatigue, and 8 to 10 when ill. In the case of more severe illness, up to 15 capsules per day are suggested. If flu-like symptoms of a ‘detoxification reaction’ appear, reduce the dosage until symptoms clear. For pets, usually one capsule per day is sufficient.

Chitosan X-tra may be taken with 1-2 grams of Vitamin C for increased effectiveness. For best results, use Chitosan X-tra with a balanced low fat diet and additional supplements like StarGold, Weight-Less, moderate exercise such as rebounding, adequate rest and 6 to 8 glasses of Microwater and/or Coral-Calcium water daily, as with any fiber supplement or health regimen. DHEA works synergistically with Chitosan X-tra, as it inhibits the enzyme G6PD responsible for storing fat. Other synergistic supplements include Digestzymes, Ester-C Complex, Chromium and Friendly-Flora. Chitosan is also reported to be safe for children and people who are slender but have high cholesterol levels. Take essential fatty acids and other fat soluble dietary supplements two to four hours before or after taking Chitosan Plus. Specific Starfire products you should be aware of are Muti Miracle, Unique E, StarGold, Garlic and any supplement containing essential fatty acids (e.g. DHA-250, Primrose Oil, Pumpkin Seed Oil, Borage Oil) or vitamins A, D, E or K.

Note: Individuals with shellfish allergies and pregnant or lactating women should consult a health care practitioner before taking this product. Check with your physician before taking chitosan if you are taking prescription medication of any kind.

Chitosan Demonstration

Materials: 10 drops of a yellow colored oil such as peanut oil (or whole milk), pure filtered water, a clear glass with no soap residues, 2 capsules of Chitosan X-tra and a fork.

Procedure:
1. Fill a clear glass with water.
2. Add 10 drops (1/4 tsp) of yellow colored oil (or whole milk).
3. Empty 2 Chitosan Plus capsules onto the mixture.
4. Gently stir with a fork for 5 to 10 seconds.
5. In about 15 seconds, the fat will be absorbed and separate out, floating or sinking depending upon the specific gravity of the resulting ‘grease ball.’
6. Remove the ‘grease ball’ with the fork if closer inspection is desired.

Fiber-Products

Back